Table 2.
Changes in the mean arterial pressure (MAP), renal sympathetic nerve activity (RSNA) and diaphragm burst amplitude (DIA burst Amp) induced by unilateral injection of bombesin (BBS; 0.3 mM) into RVLM before and after BB1 receptor blockade with BIM-23127 (3 mM) in normotensive (NT) and spontaneously hypertensive (SHR) rats.
| Group | Nanoinjections | Δ MAP (mmHg) | Δ RSNA (%) | Δ DIA burst Amp (%) |
|---|---|---|---|---|
| NT | BBS before BIM-23127 | 25.2 ± 0.5 | 47.3 ± 9.1 | 20.1 ± 8.7 |
| BBS after BIM-23127 | 1.5 ± 0.5* | 2.1 ± 0.9* | −5.9 ± 7.2 | |
| SHR | BBS before BIM-23127 | 24.8 ± 2.9 | 41.6 ± 4.6 | 24.6 ± 5.5 |
| BBS after BIM-23127 | 6.5 ± 0.6* | 4.7 ± 1.0* | −0.1 ± 4.3* |
Values are expressed as mean ± SEM.
*
different from BBS before BIM-23127; p < 0.05. n = 3–6.