Table 4.

Summary of proposed numbering scheme.

TM helix	How assigned
1	Contact with TMH 5 (either polar, glycine or small hydrophobic)
2	Contact with TMH 4 (most conserved glycine)
3	Contact with TMH 6 (most conserved small hydrophobic)
4	Contact with TMH 2 (most conserved glycine)
5	Contact with TMH 1 (either polar, glycine or small hydrophobic)
6	Contact with TMH 3 (most conserved small hydrophobic)
7	Contact with TMH 11 (most conserved polar)
8	Contact with TMH 5 (most conserved polar or small hydrophobic)
9	Contact with TMH 10 (most conserved glycine or small hydrophobic if glycine not present in sequence)
10	Contact with TMH 9 (most conserved glycine)
11	Contact with TMH 7 (most conserved polar residue)
12	Contact with TMH 9 (most conserved small hydrophobic)

In TMHs 4, 5, and 10 these correspond with the conserved glycine motifs present on those helices. In other TMHs, the residues are mostly in the same spatial location on the helix, but sometimes the position changes and thus they are easier to track via their conserved contacts rather than conservation alone.