Figure 5.

Stochastic TR binding to DNA does not show evident master regulators. The unfiltered numbers of observed binding sites for individual TRs (c) in cytoplasmic and mitochondrial RPGs in human K562 cells. Statistical preferences for several TRs emerge despite considerable randomness, which is partly due to experimental noise. For scalability, log₂(c +1) values are shown. Stochastic TR binding is also confirmed for all other analyzed human and mouse cell types (Supplementary Figure S3). The network of cRPG regulation also shows rich and highly variable binding of TRs to diverse cRPGs (Supplementary Figure S5).