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. 2016 Jan 28;44(10):4595–4609. doi: 10.1093/nar/gkw042

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© The Author(s) 2016. Published by Oxford University Press on behalf of Nucleic Acids Research.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com

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Figure 6. — cRPG regulatory binding events show highly specific and statistically significant patterns of enrichment or depletion of single transcriptional regulators, putative TR heterodimers and heterotrimers. Human cRPGs are compared to HE-NRGs and NRGs in separate panels. For single TRs, the significance of enrichment was assessed by the Wilcoxon–Mann–Whitney test, for dimers and trimers, by Fisher's Exact Test. Multiple test corrections were performed using Benjamini and Hochberg's False Discovery Rate (28). Numerical data are available in Supplementary Tables S4–S8. (A) Single TRs, cRPGs versus HE-NRGs. (B) Single TRs, cRPGs versus all NRGs. (C) Heterodimers, cRPGs versus HE-NRGs. (D) The 50 most highly enriched heterodimers, cRPGs versus HE-NRGs. (E) Heterodimers, cRPGs versus all NRGs. (F) The 50 most highly enriched heterodimers, cRPGs versus all NRGs. (G) Heterotrimers, cRPGs versus HE-NRGs. (H) The 50 most highly enriched heterotrimers, cRPGs versus HE-NRGs. (I) Heterotrimers, cRPGs versus all NRGs. (J) The 50 most highly enriched heterotrimers, cRPGs versus all NRGs.

Figure 6. — cRPG regulatory binding events show highly specific and statistically significant patterns of enrichment or depletion of single transcriptional regulators, putative TR heterodimers and heterotrimers. Human cRPGs are compared to HE-NRGs and NRGs in separate panels. For single TRs, the significance of enrichment was assessed by the Wilcoxon–Mann–Whitney test, for dimers and trimers, by Fisher's Exact Test. Multiple test corrections were performed using Benjamini and Hochberg's False Discovery Rate (28). Numerical data are available in Supplementary Tables S4–S8. (A) Single TRs, cRPGs versus HE-NRGs. (B) Single TRs, cRPGs versus all NRGs. (C) Heterodimers, cRPGs versus HE-NRGs. (D) The 50 most highly enriched heterodimers, cRPGs versus HE-NRGs. (E) Heterodimers, cRPGs versus all NRGs. (F) The 50 most highly enriched heterodimers, cRPGs versus all NRGs. (G) Heterotrimers, cRPGs versus HE-NRGs. (H) The 50 most highly enriched heterotrimers, cRPGs versus HE-NRGs. (I) Heterotrimers, cRPGs versus all NRGs. (J) The 50 most highly enriched heterotrimers, cRPGs versus all NRGs.