Table 1. Few regulators of human cRPGs have orthologs in Saccharomyces cerevisiae. A few double knockout mutants of the orthologous mouse genes are still viable.

Regulator		Mouse mutant phenotype
human	Scer	-/-	+/-
IRF1		phenotype	phenotype
SIX5		phenotype	phenotype
BRCA1		phenotype	phenotype
MYC		lethal	phenotype
KAT2A	GCN5	lethal	reduced transcription elongation
ETS1		partially lethal	phenotype
ELK1		mostly normal	normal
GTF2B	SUA7	lethal	?
ZZZ3		lethal	lethal
TAF1	TAF1		phenotype
TAF7	TAF7	lethal	phenotype
ATF2	ATF2	phenotype	phenotype
HDAC6	HDA1	normal	normal
RCOR1	SNT1	lethal	phenotype
NFKB1		phenotype	phenotype
CEPB		lethal	normal
CHD1	CHD1	phenotype	phenotype
CJUN		phenotype	phenotype
EJUN		phenotype	phenotype
JUNB		phenotype	phenotype
CTCF	CTCF	lethal	phenotype
MAFF		lethal	phenotype
NELFE		?	phenotype
NFYB	HAP3	?	phenotype
NRF1		lethal	phenotype
RFX5		phenotype	phenotype
SETDB1	SET2	lethal	phenotype/lethal