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. 2016 Mar 6;44(10):e92. doi: 10.1093/nar/gkw108

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© The Author(s) 2016. Published by Oxford University Press on behalf of Nucleic Acids Research.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com

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Figure 4. — Sequence-specific miRNA detection by Pandan sensors. (A) Fluorescence intensity fold change of Pandan sensors for several different miRNAs compared to each respective sensor + DFHBI alone. (B) Fluorescence intensity fold change of Pandan sensors as a function of miRNA concentration for miRNAs from (A). (C) Fluorescence intensity fold change of 1 μM bantam-5p Pandan sensor in the absence or presence of 1 μM bantam-5p microRNA, compared to that of 1 μM Spinach2, 1 μM CP Spinach2 (CP Spinach2) and 1 μM PNDNbantam-5p-IN (where the sequence of bantam-5p miRNA is encoded into Pandan as one continuous molecule). PNDNban-5p: Pandan sensor for bantam-5p miRNA. Fluorescence experiments were performed in triplicate. Fluorescence intensity fold change shown is with respect to sensor + DFHBI-only controls (in absence of miRNA).