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. 2016 Apr 25;44(10):4846–4854. doi: 10.1093/nar/gkw296

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© The Author(s) 2016. Published by Oxford University Press on behalf of Nucleic Acids Research.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com

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Figure 2. — Reactions and corresponding rates for the multisite competitive exchange model. (A) Generalized multisite binding model. A molecule can bind to either or both of two types of binding sites. One of the binding site types has several, N, individual sites, to which several molecules (shaded) can bind. (B and C) Binding from solution to either a primary binding site (B) or the secondary binding site (C) occurs with rate r_on, while unbinding occurs with rate k_off. (D and E) Binding to either the secondary (D) or a primary (E) binding site when already bound to the other occurs with rate r₁₂; unbinding occurs with the same rate, k_off, as when unbinding to solution (cf. panel B and C).