Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2016 Apr 25;44(10):4846–4854. doi: 10.1093/nar/gkw296

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2016. Published by Oxford University Press on behalf of Nucleic Acids Research.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com

PMC Copyright notice

Figure 3. — Effect of multiple binding sites on stability in the absence of binding partners in solution (infinite dilution). (A) Schematic illustrating the mechanism of increased stability. (B) Dissociation time in dimensionless form with times measured in multiples of the dissociation time of a single site (). Arrow shows direction of increasing number of primary binding sites (N). (Inset) Dependence on the number of primary binding sites (when r₁₂/k_off is large). (Dotted line) Limit of an infinite number of primary binding sites. (C) Dissociation time in physical units. Arrow shows direction of increasing off rate (k_off). Only one primary binding site is considered (N = 1). Main graphs calculated using Equation (4); panel B inset using Equation (5).

Inline graphic — Effect of multiple binding sites on stability in the absence of binding partners in solution (infinite dilution). (A) Schematic illustrating the mechanism of increased stability. (B) Dissociation time in dimensionless form with times measured in multiples of the dissociation time of a single site (). Arrow shows direction of increasing number of primary binding sites (N). (Inset) Dependence on the number of primary binding sites (when r₁₂/k_off is large). (Dotted line) Limit of an infinite number of primary binding sites. (C) Dissociation time in physical units. Arrow shows direction of increasing off rate (k_off). Only one primary binding site is considered (N = 1). Main graphs calculated using Equation (4); panel B inset using Equation (5).