Table 3. Brain regions showing greater and less activity in PTSD vs. TEC (voxelwise uncorrected p < 0.005 and FWHM 20 mm).
| Brain Regions | Maximum |
Cluster |
|||
|---|---|---|---|---|---|
| MNI coordinates x, y, z | SDM value | p-value | No. of voxel | Breakdown (no. of voxels) | |
| Pooled meta-analysis | |||||
| PTSD > TEC | |||||
| L superior frontal gyrus, medial orbital, BA 11 | −2, 48, −10 | 2.915 | 1.45E-05 | 1407 | R superior frontal gyrus, medial orbital, BA 11 (448) |
| L superior frontal gyrus, medial orbital, BA 11 (431) | |||||
| L gyrus rectus, BA 11 (214) | |||||
| R gyrus rectus, BA 11 (180) | |||||
| L anterior cingulate/paracingulate gyri, BA 10 (118) | |||||
| R anterior cingulate//paracingulate gyri, BA 11 (16) | |||||
| L supramarginal gyrus, BA 48 | −54, −28, 32 | 1.745 | 0.001651 | 169 | L supramarginal gyrus, BA 48 (117) |
| L superior temporal gyrus, BA 42 (51) | |||||
| L rolandic operculum, BA 48 (1) | |||||
| R middle frontal gyrus, BA 46 | 40, 42, 36 | 1.676 | 0.002254 | 59 | R middle frontal gyrus, BA 46 (59) |
| PTSD < TEC | |||||
| R Heschl’s gyrus, BA 48 | 38, −22, 8 | −1.681 | 0.000941 | 370 | R insula, BA 48 (141) |
| R rolandic operculum, BA 48 (104) | |||||
| R Heschl’s gyrus, BA 48 (85) | |||||
| External_capsule_R (29) | |||||
| R superior temporal gyrus, BA 48 (11) | |||||
| R calcarine fissure/surrounding cortex, BA 18 | 14, −78, 2 | −1.874 | 0.000476 | 362 | R calcarine fissure/surrounding cortex, BA 17 (259) |
| R lingual gyrus, BA 18 (67) | |||||
| R cuneus cortex, BA 17 (34) | |||||
| L calcarine fissure/surrounding cortex (1) | |||||
| R superior occipital gyrus, BA 18 (1) | |||||
| R fusiform gyrus, BA 37 | 38, −56, −14 | −1.69 | 0.000904 | 88 | R fusiform gyrus, BA 37 (83) |
| R cerebellum, BA 37 (5) | |||||
| R caudate nucleus | 8, 6, 8 | −1.48 | 0.004387 | 5 | R caudate nucleus (5) |
| Subgroup meta-analysis of studies without comorbidity | |||||
| PTSD > TEC | |||||
| L superior frontal gyrus, medial orbital, BA 11 | −2, 48, −12 | 3.425 | 9.29E-06 | 2012 | R superior frontal gyrus, medial orbital, BA 11 (612) |
| L superior frontal gyrus, medial orbital, BA 11 (545) | |||||
| L gyrus rectus, BA 11 (347) | |||||
| R gyrus rectus, BA 11 (242) | |||||
| L anterior cingulate/paracingulate gyri, BA 10 (210) | |||||
| R anterior cingulate/paracingulate gyri, BA 11 (52) | |||||
| L anterior corona radiata (3) | |||||
| L olfactory cortex (1) | |||||
| R middle frontal gyrus, BA 46 | 42, 42, 34 | 1.522 | 0.00243 | 100 | R middle frontal gyrus, BA 46 (100) |
| PTSD < TEC | |||||
| R fusiform gyrus, BA 37 | 42, −58, −18 | −1.743 | 0.000846 | 307 | R cerebellum, BA 37 (154) |
| R fusiform gyrus, BA 37 (151) | |||||
| R inferior temporal gyrus, BA 37 (2) | |||||
| R calcarine fissure/surrounding cortex, BA 18 | 16, −98, 0 | −1.739 | 0.00086 | 542 | R calcarine fissure/surrounding cortex, BA 17 (338) |
| R lingual gyrus, BA 18 (104) | |||||
| R cuneus cortex, BA 17 (68) | |||||
| L calcarine fissure/surrounding cortex (22) | |||||
| R superior occipital gyrus, BA 18 (9) | |||||
| L cuneus cortex, BA 18 (1) | |||||
| R rolandic operculum, BA 48 | 50, −12, 12 | −1.524 | 0.00188 | 207 | R rolandic operculum, BA 48 (68) |
| R insula, BA 48 (54) | |||||
| R Heschl’s gyrus, BA 48 (30) | |||||
| R external capsule (27) | |||||
| R superior temporal gyrus, BA 48 (25) | |||||
| R lenticular nucleus, putamen, BA 48 (3) | |||||
| Subgroup meta-analysis of studies without medication | |||||
| PTSD > TEC | |||||
| R gyrus rectus, BA 11 | 4, 46, −18 | 2.026 | 0.000549 | 648 | R superior frontal gyrus, medial orbital, BA 11 (322) |
| L superior frontal gyrus, medial orbital, BA 11 (156) | |||||
| R gyrus rectus, BA 11 (95) | |||||
| L gyrus rectus, BA 11 (53) | |||||
| L anterior cingulate/paracingulate gyri, BA 10 (22) | |||||
| R middle frontal gyrus, BA 46 | 40, 40, 30 | 2.024 | 0.000569 | 147 | R middle frontal gyrus, BA 46 (147) |
| PTSD < TEC | |||||
| R Heschl’s gyrus, BA 48 | 44, −16, 10 | −2.024 | 0.000249 | 381 | R insula, BA 48 (133) |
| R rolandic operculum, BA 48 (115) | |||||
| R Heschl’s gyrus, 0.000249 (76) | |||||
| R external capsule (36) | |||||
| R superior temporal gyrus, BA 48 (21) | |||||
| R calcarine fissure/surrounding cortex, BA 18 | 12, −92, 8 | −2.389 | 1.03E-05 | 405 | R calcarine fissure/surrounding cortex, BA 18 (270) |
| R lingual gyrus, BA 18 (76) | |||||
| R cuneus cortex (53) | |||||
| R superior occipital gyrus, BA 18 (3) | |||||
| L calcarine fissure/surrounding cortex, BA 17 (3) | |||||
| R fusiform gyrus, BA 37 | 38, −56, −14 | −2.123 | 0.000135 | 145 | R fusiform gyrus, BA 37 (125) |
| R lingual gyrus, BA 19 (16) | |||||
| R cerebellum, BA 37 (3) | |||||
| R inferior temporal gyrus, BA 37 (1) | |||||
L, Left; R, right; BA, Brodmann area; MNI, Montreal Neurological Institute; SDM, signed differential mapping.