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. 2016 Jun 2;6:27346. doi: 10.1038/srep27346

Figure 7. MiR-449a enhances radiation-induced G2/M phase arrest by repressing c-Myc in LNCaP cells.

Figure 7

(a) Cell cycle distribution in LNCaP cells transfected with miR-449a or negative control (NC) expression plasmid and treated with 4Gy of X-rays at 24 h. (b) The percentage of LNCaP cells in each phase at 24 h after exposure to 4Gy of X-rays. (c) Cell cycle distribution in LNCaP cells transfected with siRNA-c-Myc or negative control (NC) after exposure to 4Gy of X-rays at 24 h. (d) The percentage of LNCaP cells in each phase after exposure to 4Gy of X-rays 24 h. (e) Overexpression of miR-449a reduces Cdc25A, Cdc2/Cyclin B1 expression and increase Cdc2 phosphorylation in response to IR. (f) Knockdown of c-Myc reduces Cdc25A, Cdc2/Cyclin B1 expression and increases Cdc2 phosphorylation in response to IR. Data are representative of at least three independent experiments.