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. 2012 Nov 1;1(5):68–77. doi: 10.7453/gahmj.2012.1.5.015

Box 1.

A Comparison of the Reductionistic and Holistic Paradigms3

Reductionistic Paradigm Holistic Paradigm
Particularism and Reductionism: Everything in nature can be reduced to and explained by its parts—cells, molecules, and atoms—and their interaction. Holism: There is a supramolecular, holistic order in nature; holistic, hierarchical higher natural laws can be found and applied.
Materialism, mechanicism: Every living organism and process can be explained in total by laws of physics and chemistry, equivalent to a machine. Living nature is a quality of its own: There are special natural laws in living nature, above and in addition to physics and chemistry that can be found and applied.
Darwinism: The only cause of evolutionary change is chance and selection by survival advantage. Evolutionary holism: There are specific laws of nature that guide evolution.