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. Author manuscript; available in PMC: 2017 Apr 28.
Published in final edited form as: J Med Chem. 2016 Apr 13;59(8):3793–3807. doi: 10.1021/acs.jmedchem.5b02000

Figure 1.

Figure 1

Known GRK2 inhibitors. The A, B, C and D rings pack in the adenine, ribose, polyphosphate, and hydrophobic subsites of the kinase domain, respectively. That is, the A ring interacts with the hinge, whereas the D ring interacts in a pocket defined by the P-loop, the αB and αC helices in the small lobe, and by the DFG loop in the large loop.