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. Author manuscript; available in PMC: 2017 Apr 28.
Published in final edited form as: J Med Chem. 2016 Apr 13;59(8):3793–3807. doi: 10.1021/acs.jmedchem.5b02000

Figure 9.

Figure 9

Maximum contraction amplitudes of the known GRK2 inhibitor paroxetine, the lead 2, 12h, 12d,12m, and 12n before and after isoproterenol stimulation. Doses shown are the minimum inhibitory concentrations that exhibit a p-value <0.05 versus Control. Values represent the mean ± SEM for 8–10 cardiomyocytes.