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. Author manuscript; available in PMC: 2017 Apr 28.
Published in final edited form as: J Med Chem. 2016 Apr 13;59(8):3793–3807. doi: 10.1021/acs.jmedchem.5b02000

Table 2.

Kinase inhibitory activity of compounds 20 and 24.

graphic file with name nihms788676u3.jpg
Compound R1 R2 R3 GRK2
IC50 (μM)		 GRK1
IC50 (μM)		 GRK5
IC50 (μM)		 PKA
IC50 (μM)		 ROCK
IC50 (μM)
24 graphic file with name nihms788676t20.jpg H graphic file with name nihms788676t21.jpg >100 >100 >100 >100 ND
20 graphic file with name nihms788676t22.jpg Me graphic file with name nihms788676t23.jpg 4.6±3.0 >100 >100 >100 2.1±1.3

All IC50 measurements are an average of three separate experiments run in duplicate.

Errors are standard error of the mean.