Table 2. Characteristics of CHRNA7 haplotype-tagging SNPs.

Haplotype block	SNP name	rs no.	Nucleotide change	HapMap		Control		LOAD		VaD
				CHB MAF	CEU MAF	MAF	HWE p	MAF	HWE p	MAF	HWE p
1	SNP1	rs885071	T→G	0.38	0.81	0.41	0.26	0.46	0.50	0.38	0.54
1	SNP2	rs8024987	C→G	0.11	0.24	0.11	0.05	0.15	0.14	0.11	0.79
2	SNP3	rs4779565	G→T	0.38	0.41	0.34	0.11	0.39	0.69	0.35	0.71
3	SNP4	rs7402761	A→T	0.45	0	0.44	0.37	0.44	0.79	0.44	0.32
3	SNP5	rs904952	T→C	0.29	0.53	0.27	0.16	0.34	0.16	0.33	0.13
3	SNP6	rs4779978	C→T	0.38	0.31	0.36	0.83	0.35	0.65	0.32	0.50
3	SNP7	rs2651418	T→C	0.42	0.53	0.39	0.62	0.42	0.41	0.44	0.89
4	SNP8	rs7179008	A→G	0.13	0.27	0.09	0.33	0.07	0.08	0.12	0.21
4	SNP9	rs2337980	C→T	0.26	0.50	0.24	0.03	0.25	0.69	0.23	0.96

All SNPs are intronic SNPs. Abbreviations: SNP, single nucleotide polymorphism; CHB, Han Chinese in Beijing, China;

CEU, Utah residents with ancestry from northern and western European; MAF, minor allele frequency; HWE, Hardy–Weinberg equilibrium test;

LOAD, late-onset Alzheimer’s disease; VaD, vascular dementia.