Table 5. Polymorphisms of CHRNA7 rs7179008 and LOAD risk by smoking status.
| rs7179008 (SNP8) | Pinteraction | ||||
|---|---|---|---|---|---|
| 0 copies (AA) | 1 or 2 copies (AG+GG) | ||||
| Case/Control | AOR (95% CI) | Case/Control | AOR (95% CI) | ||
| Never-smokers | 164/291 | 1.00 | 27/63 | 0.54 (0.27–1.04) | 0.70 |
| Ever-smokers | 55/60 | 2.00 (1.03–3.87) | 5/15 | 0.79 (0.21–2.96) | |
All models were adjusted for age, sex, apolipoprotein E ε4, and education year and conditional on 5-year age strata. Numbers in bold indicate significant findings (P < 0.05). Abbreviations: AD, Alzheimer’s disease; SNP, single nucleotide polymorphism; AOR, adjusted odds ratio; CI, confidence interval.