Effects of 3 years of GH replacement in adulthood on BMD (percent change over baseline), stratified by the gap length between growth hormone replacement in childhood and adulthood. Study subjects were classified as being non-naïve (treated continuously or being off GH replacement shorter than 6 months before enrolment into KIMS), semi-naïve (treated in childhood, but being off GH replacement longer than 12 months before KIMS entry), and true-naïve (patients never treated in childhood, who were beginning GH replacement at KIMS entry). There is no control (untreated) group. Data shown as mean ± SE.