. Author manuscript; available in PMC: 2016 Jun 2.

Published in final edited form as: Eur J Endocrinol. 2012 Jun 18;167(3):343–351. doi: 10.1530/EJE-12-0070

Table 3.

Effects of GH replacement on lumbar spine BMD (or Z score) in randomized controlled clinical trials, including childhood onset GH deficient young adults with GHD persisting in adulthood, as well as the present uncontrolled study.

First author	Publication year	Study population size (n)	Study duration (months)	Change (expressed as mean/median) over baseline in treated group	Change (expressed as mean/median) over baseline in control group	P value
Shalet SM et al ¹⁵	2003	149	24	6.1 % (BMD)	3.1 % (BMD)	0.027
Underwood LE et al ¹⁶	2003	64	24	5.2 % (BMD)	1.3 % (BMD)	0.001
Mauras N et al ¹⁸	2005	58	24	−0.29 (Z score)	−1.08 (Z score)	0.086
Conway GS et al ¹⁷	2009	160	24	6.0 % (BMD)	2.0 % (BMD)	< 0.001
Present study		97	36	1.59 % (non-naïve); 3.91 % (semi-naïve); 6.0 % (true-naïve)^*	Not applicable	< 0.05^*

P values for percent increase in BMD (over baseline) as follows: non-naïve (P = 0.035); semi-naïve (P < 0.010) and true naïve subjects (P = 0.032).

Abbreviations: BMD: bone mineral density; GHD: growth hormone deficiency