Figure 2.

Venn diagram of intersection between the loci/genes associated with T1D or T2D and known monogenic diabetes. Over 50 susceptibility loci for common T1D and approximately 100 susceptibility loci for T2D have been identified by GWAS and candidate gene association studies. INS, GLIS3, RASGRP, COBL, RNLS, and BCAR1 are associated with both T1D and T2D. About one-third of the known monogenic diabetes genes are associated with T2D. INS and GLIS3 are the two known monogenic diabetes genes whose variants are associated with both T1D and T2D.