Figure 5.

Insulin secretion and sensitivity in men and women with NGT, IGM (IGT and/or IFG), and overt T2DM relationships between insulin sensitivity, calculated as oral glucose insulin sensitivity (OGIS) (m⁻² mL/min) (367), and insulin secretion, as the AUC of insulin (min U/L), from oral glucose tolerance test (OGTT) data. Continuous lines represent the normal metabolic condition (NGT) in both nonobese and obese males and females, ie, for declining insulin sensitivity, there is an increase of insulin secretion to compensate for insulin resistance, maintaining NGT (200). The location of the various categories of subjects is positioned by the different symbols according to their combination of insulin sensitivity and secretion. In general, the “good” area is that above the curves for the nonobese subjects, whereas the “bad” one is below and especially in the low left corner characterized by low insulin sensitivity and inadequate secretion. Original data derived from different studies carried out by the authors (199, 200).