Fig. 1.

Timeline. The black arrow represents time from diagnosis of metastatic disease until patient’s death. The orange arrow represents the duration of treatment with dabrafenib (7.1 months). Along the arrows, the − and + symbols represent the time points at which the plasma BRAF ^V600R mutation was negative and positive, respectively. a Initial CT scans (21 June 2013) showing hepatic (top) and pulmonary (bottom) lesions. b Representation of V600R mutation detected by Sanger sequencing. The black arrow points to the nucleotide changes. c Appearance of milium cysts (white arrow) secondary to dabrafenib treatment. d CT scans (8 January 2014) showing the radiological response is maintained after 5 months of treatment. The pictures correspond to the same lesions shown in a. e CT scans (17 March 2014) showing disease progression after 7.1 months of dabrafenib treatment. Top picture shows a new right adrenal mass and the bottom picture reveals the appearance of pericardial and pleural effusions. f Brain MRI showing multiple brain metastases (1 April 2014)