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. 2016 Jun 2;14:83. doi: 10.1186/s12955-016-0488-5

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© The Author(s). 2016

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 1 — Research framework. FH of MFS = family history of Marfan syndrome; Ao = sinus of Valsalva of diameter Z (= Z score), indicating the presence of aortic root dilatation (when standardized with respect to age and body size); FEN 1 = fibrillin-1 mutation; EL = ectopia lentis; OP of CV = operation on the cardiovascular system