Table 7.
Cytokine receptors on macrophages.
| Gene name | Common name | CD | Ligands and function |
|---|---|---|---|
| Ifngr1 | IFN-γ R | IFN-γ: forces M1 polarization | |
| Il1r1 | IL-1 R1 | CD121a | IL-1α and β, pro-inflammatory |
| Il1r2 | IL-1 R2 | CD121b | IL-1α and β, pro-inflammatory |
| Il4ra | IL-4 R | CD124 | IL-4: forces M2 polarization |
| Il5ra | IL-5 R | CD125 | IL-5: forces M2 polarization |
|
Il10ra Il10rb |
IL-10Rα IL-10Rβ |
CD210 | IL-10: strongly anti-inflammatory, suppresses antigen presentation (135) |
| Il13a1 | IL-13 R | CD213a | IL-13: forces M2 polarization |
| Il13a2 | IL-13 R | CD213b | IL-13: forces M2 polarization |
| Il17ra | IL-17RA | CD217 | IL-17a: activates macrophages |
| Il17rb | IL-17RB | Basophil function, asthma | |
| Il17rc | IL-17RC | Needed for IL-17A-induced CXC chemokine expression | |
| Il17rd | IL-17RD | Anti-inflammatory | |
| Il17re | IL-17RE | Receptor for IL-17C: immunity to intestinal pathogens | |
| Il27ra | IL-27R | IL-27: regulates Th1 and Treg | |
| Tgfbr1 | TGF-βR1 | TGF-β: inactivates macrophages, determining receptor of microglia | |
| Tgfbr2 | TGF-βR2 | TGF-β: inactivates macrophages | |
| Tgfbr3 | TGF-βR3 | TGF-β: inactivates macrophages |