Table 7.
MIC and susceptibility data for M. catarrhalis isolates collected during 2009–11 and 2013–14
| Years/antimicrobial agent | N | Susceptibility |
||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| MIC (mg/L) |
CLSI |
PK/PD |
EUCAST |
|||||||||
| 50% | 90% | min. | max. | %S | %I | %R | %S | %S | %I | %R | ||
| 2009–11 | ||||||||||||
| AMC | 140 | 0.25 | 0.25 | 0.03 | 1 | 100 | — | 0.0 | 100 (100) | 100 | — | 0.0 |
| azithromycin | 140 | 0.25 | >256 | 0.03 | >256 | NA | NA | NA | NA | NA | NA | NA |
| cefaclor | 140 | 2 | 8 | 0.5 | 32 | 91.4 | 4.3 | 4.3 | 1.4 | NA | NA | NA |
| cefuroximea | 140 | 2 | 8 | 0.5 | 8 | 90.0 | 10.0 | 0.0 | 27.1 | 0.0 | 90.0 | 10.0 |
| levofloxacin | 140 | 0.06 | 0.5 | 0.03 | 2 | 100 | — | — | 100 | 96.4 | — | 3.6 |
| 2013–14 | ||||||||||||
| AMC | 80 | 0.25 | 0.25 | 0.03 | 0.5 | 100 | — | 0.0 | 100 (100) | 100 | — | 0.0 |
| azithromycin | 80 | 0.03 | 0.5 | ≤0.015 | >256 | NA | NA | NA | NA | NA | NA | NA |
| cefaclor | 80 | 4 | 16 | 0.25 | 32 | 63.8 | 26.3 | 10.0 | 2.5 | NA | NA | NA |
| cefuroximea | 80 | 2 | 4 | 0.06 | 8 | 93.8 | 6.3 | 0.0 | 20.0 | 1.3 | 92.5 | 6.3 |
| levofloxacin | 80 | 0.06 | 1 | 0.015 | >32 | 91.3 | — | — | 91.3 | 91.3 | — | 8.8 |
AMC, amoxicillin/clavulanic acid; NA, no breakpoint data available.
aBreakpoints used are for cefuroxime axetil.