Table 3. Altered inter-network functional connectivity across the three groups.

Inter-iFC	HC subjects	NHE patients	MHE patients	P value (ANOVA)
aDMN - ipDMN	0.466 ± 0.197	0.482 ± 0.257	0.364 ± 0.279	0.268
aDMN - spDMN	0.154 ± 0.192	0.168 ± 0.257	0.075 ± 0.268	0.425
aDMN - SN	0.013 ± 0.200	0.279 ± 0.305†	0.303 ± 0.330*	0.005‡
aDMN - lvCEN	0.435 ± 0.228	0.384 ± 0.271	0.334 ± 0.258	0.479
aDMN - rvCEN	0.410 ± 0.166	0.437 ± 0.210	0.440 ± 0.189	0.871
aDMN - dCEN	−0.449 ± 0.214	−0.380 ± 0.210	−0.420 ± 0.262	0.625
ipDMN - spDMN	1.131 ± 0.235	1.133 ± 0.269	1.084 ± 0.311	0.811
ipDMN - SN	−0.494 ± 0.240	−0.231 ± 0.252†	−0.168 ± 0.277*	0.001‡
ipDMN - lvCEN	1.037 ± 0.264	0.949 ± 0.284	1.154 ± 0.220	0.040
ipDMN - rvCEN	0.903 ± 0.331	0.846 ± 0.239	0.971 ± 0.277	0.351
ipDMN - dCEN	0.084 ± 0.252	0.072 ± 0.232	0.145 ± 0.203	0.550
spDMN - SN	−0.545 ± 0.223	−0.354 ± 0.269†	−0.263 ± 0.215*	0.002‡
spDMN - lvCEN	0.539 ± 0.271	0.489 ± 0.216	0.617 ± 0.242	0.229
spDMN - rvCEN	0.533 ± 0.293	0.446 ± 0.246	0.503 ± 0.280	0.581
spDMN - dCEN	0.358 ± 0.219	0.318 ± 0.237	0.405 ± 0.168	0.413
SN – lvCEN	−0.320 ± 0.225	−0.092 ± 0.247†	−0.056 ± 0.249*	0.002‡
SN – rvCEN	−0.226 ± 0.279	−0.090 ± 0.269	−0.005 ± 0.271	0.050
SN – dCEN	−0.256 ± 0.237	−0.201 ± 0.251	−0.158 ± 0.244	0.466
lvCEN - rvCEN	0.984 ± 0.304	0.987 ± 0.185	1.034 ± 0.196	0.744
lvCEN – dCEN	0.185 ± 0.252	0.259 ± 0.156	0.261 ± 0.288	0.527
rvCEN – dCEN	0.001 ± 0.213	0.021 ± 0.188	0.071 ± 0.247	0.586

Note: P values in bold are <0.05. The marker ^‡indicates P < 0.05 after FDR correction for multiple comparisons. The markers * and ^†indicate a significant difference in inter-iFC between MHE and HCs and between NHE and HCs, respectively. MHE, minimal hepatic encephalopathy; NHE, patients without MHE; HC, healthy control; ANOVA, analysis of variance. a/ip/spDMN, anterior/inferior-posterior/superior-posterior DMN; lv/rv/dCEN, left-ventral/right-ventral/dorsal CEN; SN, salience network.