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. Author manuscript; available in PMC: 2016 Jun 2.
Published in final edited form as: Chem Res Toxicol. 2014 Feb 13;27(4):674–682. doi: 10.1021/tx500011m

Scheme 1.

Scheme 1

Structure of hydralazine, and DNA nitrone, and proposed formation of various free radical species from hydralazine that may induce DNA cleavage following oxidation by Cu2+ ion.