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. 2016 Jun 2;12:16. doi: 10.1186/s12993-016-0100-5

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© The Author(s) 2016

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 2 — Conjoint structural and functional effects. Structural alterations (nonsmokers > smokers) overlapped with acute drug-induced activity decreases (baseline > drug) in the insula and ventromedial PFC (green a, b). Structural alterations (nonsmokers > smokers) overlapped with acute drug-induced activity increases (drug > baseline) in the mediodorsal thalamus (orange c). Lettering corresponds to coordinates listed in Table 2. See Additional file 1: Figures S2 and S3 for visualization of overlapping and non-overlapping regions from the structural and functional meta-analyses