Table 1.
Convergent gray matter decreases associated with chronic smoking: cluster coordinates
| Cluster | Region | Volume | X | Y | Z | |
|---|---|---|---|---|---|---|
| Nonsmokers > smokers | ||||||
| 1 | Thalamus (lateral posterior nucleus) | R | 592 | 16 | −22 | 14 |
| 2 | dmPFC (BA 6) (superior frontal gyrus) | R | 576 | 16 | 24 | 52 |
| 3 | vmPFC (BA10) (superior frontal gyrus) | L | 568 | −8 | 56 | −4 |
| 4 | vlPFC (BA 10) (middle frontal gyrus) | R | 480 | 32 | 46 | 4 |
| 5 | dmPFC (BA 8) (medial frontal gyrus) | R | 480 | 10 | 40 | 36 |
| 6 | Parahippocampal gyrus | L | 432 | −20 | −34 | 0 |
| 7 | mPFC (BA10) (medial frontal gyrus) | R | 416 | 12 | 58 | 8 |
| 8 | Medial OFC (BA 11) | B | 384 | 2 | 34 | −20 |
| 9 | mPFC (BA10) (medial frontal gyrus) | L | 376 | −14 | 58 | 8 |
| 10 | Cerebellum (dentate) | R | 368 | 14 | −58 | −20 |
| 11 | Insula (BA 13) | L | 368 | −40 | 8 | 10 |
| 12 | Thalamus (medial dorsal nucleus) | B | 360 | 2 | −18 | 4 |
Numbering corresponds to brain regions shown in Fig. 1. Coordinates (X, Y, Z) of the clusters’ peak voxels are reported in Talairach space. Volume is mm3
B bilateral, R right, L left, BA Brodmann area, OFC orbitofrontal cortex, vmPFC ventromedial prefrontal cortex, vlPFC ventrolateral prefrontal cortex, dmPFC dorsomedial prefrontal cortex, mPFC medial prefrontal cortex