Table 2.
Conjoint chronic smoking-related structural alterations and acute drug-induced functional activity changes: cluster coordinates
| Cluster | Region | Volume | X | Y | Z | |
|---|---|---|---|---|---|---|
| Gray matter decreases ∩ functional decreases | ||||||
| a | Insula (BA 13) | L | 185 | −39 | 7 | 9 |
| b | vmPFC (BA10) (superior frontal gyrus) | L | 103 | −9 | 50 | −3 |
| Gray matter decreases ∩ functional increases | ||||||
| c | Thalamus (medial dorsal nucleus) | B | 142 | 2 | −14 | 11 |
Lettering corresponds to brain regions shown in Fig. 2. Coordinates (X, Y, Z) of the clusters’ peak voxels are reported in Talairach space. Volume is mm3
B bilateral, R right, L left, BA Brodmann area, vmPFC ventromedial prefrontal cortex