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. Author manuscript; available in PMC: 2017 Mar 1.
Published in final edited form as: Expert Opin Drug Saf. 2016 Feb 2;15(3):393–402. doi: 10.1517/14740338.2016.1135900

Drug name (generic) Empagliflozin

Phase IV

Indication Indicated as an adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes mellitus

Pharmacology description/method of action Inhibits the renal sodium glucose co-transporter 2 isoform thereby enhancing urinary glucose excretion

Route of administration Oral

Chemical structure D-Glucitol,1,5-anhydro-1-C-[4-chloro-3-[[4-[[(3S)-tetrahydro-3-furanyl]oxy]phenyl]methyl]phenyl]-,(1S)
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Pivotal trials EMPA-REG MONO (NCT01177813) [4]
EMPA-REG MET (NCT01159600) [5]
EMPA-REG METSU (NCT01159600) [6]
EMPA-REG PIO (NCT01210001) [7]
EMPA-REG MDI (NCT01306214) [8]
EMPA-REG H2H SU (NCT01167881) [9]