Table 3.

Amino acid variations in Delhi samples in comparison with ESCA lineage and other Indian samples

a: Amino acid variations of Delhi samples in nsP1

Name of protein

Sample Site

128

253

314

376

488

CHIKV nsp1

S27- African Prototype

T

K

M

T

Q

Andhra Pradesh

K

K

L/M

M

R

(n = 5)

Gujarat

K

K

L/M

M

R

(n = 5)

Karnataka

K

K

L

M

R

(n = 3)

Kerala

K

K

L/M

M

R

(n = 9)

Rajasthan

K

K

M

M

R

(n = 2)

Tamil Nadu

K

K

M

M

R

(n = 1)

West Bengal

T

T

M

T

Q

(n = 1)

Maharashtra

T/K

T/K

M

M

R

(n = 3)

Delhi

K

K

M

M

R

(n = 14)

b: Amino acid variations of Delhi samples in nsP2

Name of protein

Sample Site

48

54

181

237

238

329

374

411

539

708

793

CHIKV nsp2

S27- African Prototype

V

N

V

L

L

K

H

N

L

L

A

Andhra Pradesh

V

N

V

L

L

K

Y

N

L

L

V

(n = 5)

Gujarat

V

N

V

L

L

K

Y

N

L

L

V

(n = 5)

Karnataka

V

N

V/A

L

L

K

Y

N

L

L

V

(n = 3)

Kerala

A/V

N

V

R/L

P/L

E/K

Y

D/N

L/S

P/L

V

(n = 9)

Rajasthan

V

N

V

L

L

K

Y

N

L

L

V

(n = 2)

Tamil Nadu

V

N

V

L

L

K

Y

N

L

L

V

(n = 1)

West Bengal

V

S

V

L

L

K

H

N

L

L

A

(n = 1)

Maharashtra

V

S/N

V

L

L

K

H/Y

N

L

L

V/A

(n = 3)

Delhi

V

N

V

L

L

K

Y

N

L

L

V

(n = 14)

c: Amino acid variations of Delhi samples in nsP3

Name of protein

Sample Site

175

217

341

353

501

CHIKV nsp3

S27- African Prototype

V

Y

T

I

L

Andhra Pradesh

I

H

T/M

I

L

(n = 5)

Gujarat

I

H

T

I

S/L

(n = 5)

Karnataka

I

H

T

I

S/L

(n = 3)

Kerala

I

H

T

I

L

(n = 9)

Rajasthan

I

H

T

I

L

(n = 2)

Tamil Nadu

I

H

M

I

L

(n = 1)

West Bengal

V

Y

T

T

L

(n = 1)

Maharashtra

I/V

Y/H

T

I/T

L

(n = 3)

Delhi

I

H

T

I

L

(n = 14)

d: Amino acid variations of Delhi samples in nsP4

Name of protein

Sample Site

43

85

90

235

CHIKV nsp4

S27- African Prototype

A

R

S

Q

Andhra Pradesh

A

R

S

Q

(n = 5)

Gujarat

A

R

S

Q

(n = 5)

Karnataka

A

R

S

Q

(n = 3)

Kerala

A

R

S

Q

(n = 9)

Rajasthan

A

R

S

Q

(n = 2)

Tamil Nadu

A

R

S

Q

(n = 1)

West Bengal

L

K

A

R

(n = 1)

Maharashtra

L/A

K/R

A/S

R/Q

(n = 3)

Delhi

A

R

S

Q

(n = 14)