Table 5.
The tables show the predicted ELMs for the coevolving residues along with the coevolving positions of amino acid residue of non-structural proteins of Chikungunya virus. The coevolving amino acid residues are written in the bracket “()”
| a: ELMs for coevolving residues in nsP1 where, | |
| Position (residue) | ELMsa |
| 3(S) | LIG_WD40_WDR5_VDV_1, LIG_LIR_Gen_1, DEG_Nend_UBRbox_2 |
| 75(D) | DRK,CLV_NRD_NRD_1 |
| 172(V) | DOC_MAPK_1 |
| 176(V) | DOC_MAPK_1 |
| 291(M) | MOD_ProDKin_1, MOD_PKA_1, MOD_PKA_1, DOC_WW_Pin1_4 |
| 383(L) | LIG_SH2_STAT5 |
| 409(V) | DOC_CYCLIN_1 |
| 453(G) | MOD_GSK3_1 |
| 472(R) | TRG_LysEnd_APsAcLL_1,DOC_CYCLIN_1, CLV_PCSK_SKI1_1 |
| 485(N) | MOD_GlcNHglycan |
| 486(A) | MOD_GlcNHglycan |
| 506(H) | DEG_APCC_DBOX_1 |
| 517(E) | LIG_TRAF2_1 |
| b: ELMs for coevolving residues in nsP2 | |
| Position (residue) | Motifsb |
| 16(L) | MOD_GSK3_1,LIG_FHA_1 |
| 170(K) | LIG_SH3_1,LIG_SH3_3 |
| 273(L) | DOC_MAPK_1 |
| 338(M) | LIG_SUMO_SIM_par_1 |
| 463(S) | MOD_GSK3_1 |
| 510(K) | MOD_ProDKin_1,LIG_14-3-3_3,DOC_WW_Pin1_4 |
| 54(S) | LIG_Integrin_isoDGR_1 |
| 642(Y) | MOD_NEK2_1,MOD_GlcNHglycan |
| 683(V) | LIG_LIR_LC3C_4,LIG_SUMO_SIM_anti_2 |
| 69(V) | TRG_LysEnd_APsAcLL_1,LIG_SH3_3,LIG_eIF4E_1 |
| 768(S) | MOD_NEK2_1 |
| c: ELMs for coevolving residues in nsP3 | |
| Position (residue) | Motifsc |
| 122(T) | LIG_14-3-3_2,MOD_NEK2_1,MOD_PKA_2 |
| 132(M) | CLV_C14_Caspase3-7,MOD_GSK3_1 |
| 327(S) | LIG_TRAF2_1,MOD_CK1_1,MOD_CK2_1,MOD_GSK3_1,MOD_PKA_2 |
| 330(S) | MOD_GlcNHglycan,LIG_TRAF2_1,MOD_CK1_1,MOD_CK2_1,MOD_GSK3_1,MOD_PKA_2 |
| 332(Q) | MOD_GlcNHglycan,LIG_TRAF2_1,MOD_CK1_1,MOD_CK2_1,MOD_GSK3_1 |
| 349(V) | MOD_PLK |
| 361(D) | CLV_C14_Caspase3-7 |
| 377(H) | MOD_GSK3_1 |
| 378(T) | MOD_GSK3_1 |
| 381(S) | MOD_GSK3_1 |
| 395(S) | LIG_SH3_3 |
| 397(V) | LIG_SH3_3 |
| 408(R) | CLV_PCSK_SKI1_1,MOD_N-GLC_1,DOC_CYCLIN_1,DOC_MAPK_1,MOD_PKB_1,TRG_ER_diArg_1 |
| 411(T) | CLV_PCSK_SKI1_1,MOD_N-GLC_1,DOC_CYCLIN_1,DOC_MAPK_1,MOD_CK2_1,MOD_PKB_1 |
| 434(L) | DEG_APCC_DBOX_1 |
| 436(P) | DEG_APCC_DBOX_1 |
| 437(A) | DEG_APCC_DBOX_1 |
| 452(Q) | DOC_PP2B_LxvP_1 |
| 455(P) | MOD_CK2_1 |
| 462(N) | LIG_SH3_3,MOD_CK1_1 |
| 463(H) | LIG_SH3_3 |
| 464(P) | LIG_EVH1_2,LIG_SH3_3,MOD_GSK3_1 |
| 466(I) | LIG_EVH1_2,MOD_GSK3_1 |
| d: ELMs for coevolving residues in nsP4 | |
| Position (residue) | Motifsd |
| 113(V) | MOD_CK2_1,MOD_GSK3_1,MOD_PKA_2 |
| 137(S) | DOC_USP7_1,MOD_GSK3_1 |
| 15(K) | DOC_MAPK_1,MOD_GSK3_1,MOD_PKA_2 |
| 182(S) | LIG_14-3-3_3,MOD_CK1_1,MOD_GSK3_1 |
| 20(S) | DOC_MAPK_1,MOD_GSK3_1,MOD_PKA_2 |
| 512(H) | MOD_GSK3_1,MOD_NEK2_1 |
| 571(Y) | MOD_CK2_1 |
| 582(A) | LIG_SUMO_SIM_anti_2 |
| 603(V) | DOC_MAPK_1,MOD_NEK2_2 |
| 77(I) | LIG_Actin_WH2_2 |
| 79(R) | CLV_PCSK_FUR_1,DOC_MAPK_1,LIG_Actin_WH2_2 |
| 81(K) | CLV_PCSK_FUR_1,CLV_PCSK_PC1ET2_1,DOC_MAPK_1,LIG_Actin_WH2_2 |
| 90(A) | LIG_FHA_1,LIG_SH2_STAT5,LIG_SH3_3,MOD_ProDKin_1,DOC_WW_Pin1_4 |
a LIG_WD40_WDR5_VDV_1 WDR5 WD40 repeat (blade 5,6)-binding ligand, LIG_LIR_Gen_1 Atg8 protein family ligands, DEG_Nend_UBRbox_2 N-degron, CLV_NRD_NRD_1 NRD cleavage site, DOC_MAPK_1 MAPK docking motifs, MOD_ProDKin_1 MAPK Phosphorylation Site, MOD_PKA_1 PKA Phosphorylation site, DOC_WW_Pin1_4 WW domain ligands, LIG_SH2_STAT5 SH2 ligand, DOC_CYCLIN_1 Cyclin recognition site, MOD_GSK3_1 GSK3 phosphorylation site, TRG_LysEnd_APsAcLL_1 Endosome-Lysosome-Basolateral sorting signals, CLV_PCSK_SKI1_1 PCSK cleavage site, MOD_GlcNHglycan Glycosaminoglycan attachment site, DEG_APCC_DBOX_1 APCC-binding Destruction motifs, LIG_TRAF2_1 TRAF2 binding site
b MOD_GSK3_1 GSK3 phosphorylation site, LIG_FHA_1 FHA phosphopeptide ligands, LIG_SH3_1 SH3 ligand, LIG_SH3_3 SH3 ligand, DOC_MAPK_1 MAPK docking motifs, LIG_SUMO_SIM_par_1 SUMO interaction site, MOD_ProDKin_1 MAPK Phosphorylation Site, LIG_14-3-3_3 14-3-3 ligand, DOC_WW_Pin1_4 WW domain ligands, LIG_Integrin_isoDGR_1 Integrin binding sites, MOD_NEK2_1 NEK2 phosphorylation site, MOD_GlcNHglycan Glycosaminoglycan attachment site, LIG_LIR_LC3C_4 Atg8 protein family ligands, LIG_SUMO_SIM_anti_2 SUMO interaction site, TRG_LysEnd_APsAcLL_1 Endosome-Lysosome-Basolateral sorting signals, LIG_eIF4E_1 eIF4E binding motif
c LIG_14-3-3_2 14-3-3 ligand, MOD_NEK2_1 NEK2 phosphorylation site, MOD_PKA_2 PKA Phosphorylation site, MOD_GSK3_1 GSK3 phosphorylation site, LIG_TRAF2_1 TRAF2 binding site, MOD_CK1_1 CK1 Phosphorylation site, MOD_PLK Plk phosphorylation site, LIG_SH3_3 SH3 ligand, MOD_N-GLC_1 N-glycosylation site, DOC_CYCLIN_1 Cyclin recognition site, MOD_PKB_1 PKB Phosphorylation site, TRG_ER_diArg_1 di Arginine retention/retrieving signal, DOC_PP2B_LxvP_1 Calcineurin (PP2B)-docking motif LxvP, LIG_EVH1_2 EVH1 ligands
d MOD_CK2_1 CK2 Phosphorylation site, MOD_GSK3_1 GSK3 phosphorylation site, MOD_PKA_2 PKA Phosphorylation site, DOC_USP7_1 USP7 binding motif, LIG_14-3-3_3 14-3-3 ligand, MOD_CK1_1 CK1 Phosphorylation site, MOD_NEK2_1 NEK2 phosphorylation site, LIG_Actin_WH2_2 Actin-binding motifs, CLV_PCSK_FUR_1 PCSK cleavage site, LIG_FHA_1 FHA phosphopeptide ligands, LIG_SH2_STAT5 SH2 ligand, LIG_SH3_3 SH3 ligand, MOD_ProDKin_1 MAPK Phosphorylation Site, DOC_WW_Pin1_4 WW domain ligands