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. 2016 Jun 1;6:27119. doi: 10.1038/srep27119

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Copyright © 2016, Macmillan Publishers Limited

This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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A total of 36 miRNA transcripts were found to be differentially expressed in the villi and crypts of BL-6 WT and PepT1 KO mice; those having P < 0.05 and signal >500 are shown (n = 4). (a1,a2) In BL-6 WT crypts compared to BL-6 WT villi, 20 miRNAs were lower expressed (blue spots below purple spots), 1 displayed similar expression levels, and 15 were higher expressed (blue spots above purple spots). (b1,b2) In PepT1 KO crypts compared to PepT1 KO villi, 17 miRNAs were lower expressed (red spots below green spots), 12 displayed similar expression levels in the two tissues, and 7 were higher expressed (red spots above green spots). (c1,c2). In PepT1 KO villi compared to BL-6 WT villi, 15 miRNAs were down-regulated (green spots below purple spots), 10 displayed similar expression levels, and 11 were up-regulated (green spots above purple spots). (d1,d2) In PepT1 KO crypts compared to BL-6 WT crypts, 11 miRNAs were down-regulated (red spots below blue spots), 11 displayed similar expression levels, and 14 were up-regulated (red spots above blue spots).