Table 1.

Morphological parameters and cardiac function

Parameters	WT baseline (n=7)	WT + IS 2d (n=6)	WT + IS 2W (n=8)	SIRT3 KO baseline (n=7)	SIRT3 KO + IS 2d (n=5)	SIRT3 KO + IS 2W (n=5)
LVESD (mm)	2.15 ± 0.08	3.04 ± 0.15*	2.65 ± 0.12* #	2.19 ± 0.05	3.14 ± 0.14*	3.25 ± 0.12* ‡
LVEDD (mm)	3.54 ± 0.12	4.04 ± 0.13*	3.84 ± 0.10	3.42 ± 0.09	3.76 ± 0.10	3.88 ± 0.18*
LVESV (μl)	15.60 ± 1.49	36.98 ± 4.65*	26.46 ± 2.70* #	16.11 ± 1.01	39.51 ± 4.35*	42.84 ± 3.66* ‡
LVEDV (μl)	52.58 ± 4.19	72.22 ± 5.82*	64.22 ± 4.02	48.58 ± 3.33	60.75 ± 3.99	65.77 ± 7.13*
SV (μl)	37.12 ± 2.72	35.27 ± 1.72	37.77 ± 2.13	32.44 ± 2.55	21.24 ± 3.52* †	22.93 ± 3.92* ‡
LVAW, s (mm)	1.17 ± 0.06	1.06 ± 0.04	0.89 ± 0.04	1.16 ± 0.06	0.64 ± 0.09	0.71 ± 0.04
LVAW, d (mm)	0.71 ± 0.05	0.73 ± 0.03	0.64 ± 0.03	0.71 ± 0.05	0.47 ± 0.08* †	0.51 ± 0.03*
LVPW, s (mm)	0.99 ± 0.05	0.84 ± 0.03*	0.86 ± 0.04*	0.88 ± 0.04	0.72 ± 0.06*	0.89 ± 0.02#
LVPW, d (mm)	0.58 ± 0.04	0.60 ± 0.04	0.52 ± 0.02	0.61 ± 0.01	0.62 ± 0.05	0.64 ± 0.03‡

Data are means ± s.e.m.

^*p < 0.05 vs. corresponding baseline;

^#p < 0.05 vs. corresponding IS 2d;

^†p<0.05 vs. WT+IS 2d;

^‡p<0.05 vs. WT+IS 2W.

p values were determined using two-way ANOVA to test the interaction between gene deletion and MI time. LVESD, left ventricle end-systolic diameter; LVEDD, left ventricle end-diastolic diameter; LVESV, left ventricle end-systolic diameter volume; LVEDV, left ventricle end-diastolic volume; SV, stroke volume; EF, ejection fraction; FS, fractional shortening; LVAW, s, left ventricle systolic anterior wall thickness; LVAW, d, left ventricle diastolic anterior wall thickness; LVPW, s, left ventricle systolic posterior wall thickness; LVPW, d, left ventricle diastolic posterior wall thickness.