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. Author manuscript; available in PMC: 2017 Feb 1.
Published in final edited form as: Cell Signal. 2015 Nov 11;28(2):7–22. doi: 10.1016/j.cellsig.2015.11.005

Figure 6. NFκB and JNK pathways mediate TLR3 ligands-induced increase in HIV-1 LTR activity in both TZM-bl and U38 cells.

Figure 6

Exposure of TZM-bl (A) or U38 cells (B) to PIC (25 or 50 μg/ml) for 48 h increased HIV-1 LTR activity. PIC-induced HIV-1 LTR activity in TZM-bl and U38 cells could be blocked by the inhibitor of NFκB transcriptional activation (481406), the JNK inhibitor (420119), the inhibitor of c-Jun/JNK complex (420130), and the MEKK7/MKK7 inhibitor (5ZO). *P<0.05, **P<0.01, ***P<0.001; p-values for inhibitors-treated samples are in comparison to LTR activity in PIC-treated cells.