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. 2016 Jun 2;6:27310. doi: 10.1038/srep27310

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Copyright © 2016, Macmillan Publishers Limited

This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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Venn diagrams show the number of genes significantly (a) up-regulated and (b) down-regulated; green, blue and yellow circles represent the changes from PM to MC, MC to CM, and PM to CM, respectively. (c) Similarity of the expression profiles between genes with hierarchical clustering is shown above the heatmap. Intensity of color indicates expression levels, and the three major clusters represent the PM, MC and CM stages.