Table 2.

Validation of the DNA-me differences between EDIC Study case and control groups using amplicon-seq

Gene	Cell	CpG location*	Case mean (%)	Control mean (%)	Difference (%)	P value†
CYB5B	WB	16:69,457,645	91.8	94.7	−2.9	7.9E-03
CYB5B	WB	16:69,457,652	88.7	91.5	−2.8	4.7E-02
CYB5B	WB	16:69,457,738	86.1	89.1	−3.0	1.4E-02
TXNIP	WB	1:145,441,517	55.5	72.4	−16.9	9.2E-05
TXNIP	WB	1:145,441,526	56.2	72.7	−16.5	1.3E-04
TXNIP	WB	1:145,441,552	58.8	69.7	−10.9	3.3E-05
LINC00649	WB	21:35,320,667	41.0	48.4	−7.4	1.6E-03
LINC00649	WB	21:35,320,677	20.4	28.2	−7.9	1.6E-03
MBOAT7	WB	19:54,677,166	57.7	44.6	13.1	6.6E-03
CLCN7	WB	16:1,510,620	76.7	60.9	15.8	4.4E-04
CLCN7	WB	16:1,510,813	54.1	43.4	10.8	1.3E-02
CLCN7	WB	16:1,510,849	71.1	64.8	6.3	3.2E-02
CLCN7	WB	16:1,510,879	54.6	43.8	10.7	4.4E-02
CLCN7	WB	16:1,510,897	32.3	25.0	7.3	3.4E-02
CLCN7	WB	16:1,510,922	80.2	73.8	6.4	3.7E-02
PRKCE	WB	2:46,396,825	73.8	87.8	−14.0	3.2E-02
PRKCE	Mo	2:46,396,825	71.8	93.4	−21.6	1.1E-02
CLCN7	Mo	16:1,509,221	62.6	53.2	9.5	4.4E-02
CLCN7	Mo	16:1,509,206	58.2	46.3	12.0	2.7E-02
CLCN7	Mo	16:1,507,865	92.8	83.3	9.5	5.2E-02
CLCN7	Mo	16:1,507,958	23.3	15.8	7.4	1.8E-03
TXNIP	Mo	1:145,441,517	60.1	73.1	−12.0	2.9E-05
TXNIP	Mo	1:145,441,526	61.7	73.7	−12.0	2.4E-05
TXNIP	Mo	1:145,441,552	60.3	67.8	−7.5	2.8E-04

Mo, Monos.

^*Chromosome:genomic location.

^†Wilcoxon rank-sum test.