Table 3.
Age-adjusted hazard ratios (HRs) and 95 % confidence intervals (CIs) for the association between BMI and 15-year all-cause and breast cancer-specific mortality stratified by gene methylation status (methylated vs. unmethylated tumors) among 1308 women diagnosed with a first primary breast cancer, Long Island Breast Cancer Study Project
| All-cause mortality |
Breast cancer-specific mortality |
|||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Unmethylated | Methylated | Unmethylated | Methylated | |||||||||
| Gene promoter | ||||||||||||
| Body Mass Index (BMI) categories | No. deaths/cases | HR | 95 % CI | No. deaths/cases | HR | 95 % CI | No. deaths/cases | HR | 95 % CI | HR | 95 % CI | |
| APC | ||||||||||||
| BMI < 25 kg/m2 | 55/195 | 1.00 | Reference | 52/158 | 1.00 | Reference | 25/195 | 1.00 | Reference | 23/158 | 1.00 | Reference |
| BMI 25–29.9 kg/m2 | 49/119 | 1.26 | (0.86, 1.87) | 44/131 | 0.99 | (0.66, 1.47) | 17/119 | 1.28 | (0.69, 2.40) | 20/131 | 1.03 | (0.57, 1.88) |
| BMI ≥ 30 kg/m2 | 32/94 | 0.99 | (0.64, 1.53) | 51/96 | 1.97 | (1.33, 2.09) | 9/94 | 0.81 | (0.38, 1.76) | 29/96 | 2.47 | (1.43, 4.27) |
| p interaction | 0.001 | 0.003 | ||||||||||
| BRCA1 | ||||||||||||
| BMI < 25 kg/m2 | 45/153 | 1.00 | Reference | 71/221 | 1.00 | Reference | 18/153 | 1.00 | Reference | 33/221 | 1.00 | Reference |
| BMI 25–29.9 kg/m2 | 34/104 | 0.96 | (0.61, 1.49) | 63/163 | 1.11 | (0.79, 1.57) | 9/104 | 0.78 | (0.35, 1.75) | 29/163 | 1.24 | (0.75, 2.05) |
| BMI ≥ 30 kg/m2 | 33/88 | 1.20 | (0.77, 1.88) | 54/114 | 1.45 | (1.02, 2.06) | 10/88 | 1.09 | (0.50, 2.39) | 29/114 | 1.89 | (1.14, 3.12) |
| p interaction | 0.489 | 0.151 | ||||||||||
| CDH1 | ||||||||||||
| BMI < 25 kg/m2 | 98/319 | 1.00 | Reference | 7/19 | 1.00 | Reference | 44/319 | 1.00 | Reference | <5/19 | Not estimateda | |
| BMI 25–29.9 kg/m2 | 78/218 | 1.03 | (0.77, 1.39) | 7/16 | 1.38 | (0.47, 4.01) | 26/218 | 0.92 | (0.56, 1.49) | <5/16 | not estimated | |
| BMI > 30 kg/m2 | 76/177 | 1.34 | (1.00, 1.81) | 5/9 | 2.15 | (0.67, 6.95) | 36/177 | 1.64 | (1.05, 2.56) | <5/9 | Not estimated | |
| p interaction | 0.400 | - | ||||||||||
| CYCLIND2 | ||||||||||||
| BMI < 25 kg/m2 | 83/276 | 1.00 | Reference | 22/62 | 1.00 | Reference | 40/276 | 1.00 | Reference | 6/62 | 1.00 | Reference |
| BMI 25–29.9 kg/m2 | 63/184 | 1.04 | (0.75, 1.45) | 22/50 | 1.07 | (0.59, 1.94) | 20/184 | 0.80 | (0.47, 1.36) | 9/50 | 2.01 | (0.70, 5.72) |
| BMI > 30 kg/m2 | 59/149 | 1.30 | (0.93, 1.81) | 22/37 | 1.64 | (0.91, 2.96) | 28/149 | 1.42 | (0.87, 2.31) | 10/37 | 3.41 | (1.21, 9.59) |
| p interaction | 0.480 | 0.084 | ||||||||||
| DAPK | ||||||||||||
| BMI < 25 kg/m2 | 92/297 | 1.00 | Reference | 13/41 | 1.00 | Reference | 39/297 | 1.00 | Reference | 7/41 | 1.00 | Reference |
| BMI 25–29.9 kg/m2 | 70/198 | 0.99 | (0.73, 1.35) | 15/36 | 1.45 | (0.69, 3.05) | 22/198 | 0.88 | (0.52, 1.48) | 7/36 | 1.35 | (0.47, 3.86) |
| BMI ≥ 30 kg/m2 | 67/156 | 1.33 | (0.97, 1.82) | 14/30 | 1.63 | (0.77, 3.47) | 32/156 | 1.69 | (1.05, 2.70) | 6/30 | 1.50 | (0.50, 4.50) |
| p interaction | 0.353 | 0.347 | ||||||||||
| ESR1 | ||||||||||||
| BMI < 25 kg/m2 | 57/195 | 1.00 | Reference | 58/175 | 1.00 | Reference | 30/195 | 1.00 | Reference | 21/175 | 1.00 | Reference |
| BMI 25–29.9 kg/m2 | 55/153 | 1.04 | (0.72, 1.51) | 42/110 | 1.13 | (0.76, 1.69) | 17/153 | 0.78 | (0.43, 1.43) | 21/110 | 1.61 | (0.88, 2.95) |
| BMI ≥ 30 kg/m2 | 49/108 | 1.53 | (1.04, 2.24) | 38/94 | 1.15 | (0.77, 1.74) | 20/108 | 1.48 | (0.84, 2.62) | 19/94 | 1.67 | (0.89, 3.12) |
| p interaction | 0.202 | 0.082 | ||||||||||
| GSTP1 | ||||||||||||
| BMI < 25 kg/m2 | 65/247 | 1.00 | Reference | 40/91 | 1.00 | Reference | 25/247 | 1.00 | Reference | 21/91 | 1.00 | Reference |
| BMI 25–29.9 kg/m2 | 56/169 | 1.14 | (0.80, 1.63) | 29/65 | 0.89 | (0.55, 1.44) | 19/169 | 1.16 | (0.64, 2.12) | 20/65 | 0.70 | (0.3, 1.48) |
| BMI ≥ 30 kg/m2 | 54/130 | 1.54 | (1.08, 2.21) | 27/56 | 1.07 | (0.65, 1.74) | 26/130 | 2.12 | (1.22, 3.68) | 12/56 | 1.05 | (0.52, 2.14) |
| p interaction | 0.192 | 0.080 | ||||||||||
| HIN1 | ||||||||||||
| BMI < 25 kg/m2 | 47/140 | 1.00 | Reference | 58/198 | 1.00 | Reference | 17/140 | 1.00 | Reference | 29/198 | 1.00 | Reference |
| BMI 25–29.9 kg/m2 | 28/78 | 1.00 | (0.63, 1.60) | 57/156 | 1.10 | (0.76, 1.59) | 12/78 | 1.25 | (0.59, 2.62) | 17/156 | 0.82 | (0.45, 1.49) |
| BMI ≥ 30 kg/m2 | 21/63 | 0.95 | (0.57, 1.59) | 60/123 | 1.65 | (1.15, 2.36) | 9/63 | 1.12 | (0.50, 2.53) | 29/123 | 1.95 | (1.16, 3.28) |
| p interaction | 0.077 | 0.071 | ||||||||||
| CDKN2A | ||||||||||||
| BMI < 25 kg/m2 | 102/334 | 1.00 | Reference | <5/8 | Not estimated | 45/334 | 1.00 | Reference | <5/8 | Not estimated | ||
| BMI 25–29.9 kg/m2 | 86/226 | 1.11 | (0.83, 1.48) | 6/16 | Not estimated | 31/226 | 1.09 | (0.69, 1.73) | 6/16 | Not estimated | ||
| BMI ≥ 30 kg/m2 | 76/180 | 1.37 | (1.02, 1.84) | <5/6 | Not estimated | 34/180 | 1.56 | (1.00, 2.44) | <5/6 | nOt estimated | ||
| p interaction | - | - | ||||||||||
| PR | ||||||||||||
| BMI < 25 kg/m2 | 94/321 | 1.00 | Reference | 22/53 | 1.00 | Reference | 37/321 | 1.00 | Reference | 14/53 | 1.00 | Reference |
| BMI 25–29.9 kg/m2 | 85/238 | 1.07 | (0.79, 1.43) | 12/29 | 1.33 | (0.65, 2.71) | 31/238 | 1.23 | (0.76, 2.00) | 7/29 | 1.05 | (0.42, 2.61) |
| BMI ≥ 30 kg/m2 | 78/183 | 1.40 | (1.04, 1.89) | 9/19 | 1.15 | (0.53, 2.50) | 34/183 | 1.91 | (1.19, 3.07) | 5/19 | 1.09 | (0.39, 3.05) |
| p interaction | 0.400 | 0.286 | ||||||||||
| RARB | ||||||||||||
| BMI < 25 kg/m2 | 75/242 | 1.00 | Reference | 30/96 | 1.00 | Reference | 30/242 | 1.00 | Reference | 16/96 | 1.00 | Reference |
| BMI 25–29.9 kg/m2 | 57/166 | 1.01 | (0.72, 1.43) | 28/68 | 1.18 | (0.70, 1.97) | 15/166 | 0.77 | (0.41, 1.44) | 14/68 | 1.35 | (0.65, 2.79) |
| BMI ≥ 30 kg/m2 | 58/139 | 1.28 | (0.91, 1.81) | 23/47 | 1.66 | (0.96, 2.85) | 27/139 | 1.64 | (0.97, 2.77) | 11/47 | 1.81 | (0.84, 3.90) |
| p interaction | 0.434 | 0.284 | ||||||||||
| RASSF1A | ||||||||||||
| BMI < 25 kg/m2 | 18/51 | 1.00 | Reference | 87/287 | 1.00 | Reference | 6/51 | 1.00 | Reference | 40/287 | 1.00 | Reference |
| BMI 25–29.9 kg/m2 | 7/29 | 0.61 | (0.25, 1.49) | 78/205 | 1.15 | (0.84, 1.55) | 2/29 | 0.57 | (0.11, 2.91) | 27/205 | 1.02 | (0.63, 1.67) |
| BMI ≥ 30 kg/m2 | 9/32 | 0.76 | (0.34, 1.70) | 72/154 | 1.53 | (1.12, 2.09) | 5/32 | 1.28 | (0.38, 4.36) | 33/154 | 1.77 | (1.12, 2.82) |
| p interaction | 0.050 | 0.355 | ||||||||||
| TWIST1 | ||||||||||||
| BMI < 25 kg/m2 | 93/291 | 1.00 | Reference | 12/47 | 1.00 | Reference | 40/291 | 1.00 | Reference | 6/47 | 1.00 | Reference |
| BMI 25–29.9 kg/m2 | 63/191 | 0.91 | (0.66, 1.25) | 22/43 | 2.12 | (1.04, 4.31) | 19/191 | 0.70 | (0.41, 1.22) | 10/43 | 2.49 | (0.90, 6.86) |
| BMI ≥ 30 kg/m2 | 65/162 | 1.19 | (0.87, 1.63) | 16/24 | 3.21 | (1.51, 6.83) | 31/162 | 1.39 | (0.87, 2.24) | 7/24 | 4.25 | (1.43, 12.70) |
| p interaction | 0.010 | 0.015 | ||||||||||
a
Point estimate was not calculated because cell sizes less than five