Table 4.
Age-adjusted hazard ratios (HRs) and 95 % confidence intervals (CIs) for the association between body mass index (BMI) and 15-year all-cause and breast cancer-specific mortality among a population-based sample of 1308 women with a first primary breast cancer, stratified by global methylation status (measured by LUMA and LINE-1), Long Island Breast Cancer Study Project
| Global marker | All-cause mortality |
Breast cancer-specific mortality |
||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| BMI categories | No. deaths/cases | HR | 95 % CI | No. deaths/cases | HR | 95 % CI | No. deaths/cases | HR | 95 % CI | No. deaths/cases | HR | 95 % CI |
| LUMA methylationa | <Median (0.556) | >Median | <Median (0.556) | >Median | ||||||||
| BMI < 25 kg/m2 | 44/164 | 1.00 | Reference | 80/307 | 1.00 | Reference | 21/164 | 1.00 | Reference | 33/307 | 1.00 | Reference |
| BMI 25–29.9 kg/m2 | 33/111 | 0.91 | (0.58, 1.44) | 78/226 | 1.11 | (0.81, 1.52) | 12/111 | 0.82 | (0.40, 1.67) | 35/226 | 1.50 | (0.92, 2.43) |
| BMI ≥ 30 kg/m2 | 46/88 | 1.81 | (1.19, 2.74) | 56/150 | 1.23 | (0.87, 1.73) | 25/88 | 2.61 | (1.45, 4.69) | 22/150 | 1.50 | (0.87, 2.60) |
| p interaction | 0.035 | 0.007 | ||||||||||
| LINE-1 methylationb | >Median(78.735) | <Median | >Median (78.735) | <Median | ||||||||
| BMI < 25 kg/m2 | 49/183 | 1.00 | Reference | 62/202 | 1.00 | Reference | 20/183 | 1.00 | Reference | 32/202 | 1.00 | Reference |
| BMI 25–29.9 kg/m2 | 49/133 | 1.12 | (0.76, 1.65) | 54/151 | 1.01 | (0.71, 1.43) | 21/133 | 1.52 | (0.82, 2.81) | 23/151 | 1.05 | (0.62, 1.77) |
| BMI ≥ 30 kg/m2 | 50/98 | 1.55 | (1.06, 2.28) | 50/106 | 1.40 | (0.97, 2.01) | 23/98 | 2.46 | (1.36, 4.46) | 25/106 | 1.75 | (1.04, 2.97) |
| p interaction | 0.621 | 0.313 | ||||||||||
a
LUMA methylation median value 0.556, high levels of LUMA hypothesized to be deleterious
b
LINE-1 methylation median value 78.735, low levels of LINE-1 hypothesized to be deleterious