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. Author manuscript; available in PMC: 2017 Jan 7.
Published in final edited form as: Breast Cancer Res Treat. 2016 Jan 7;155(2):355–363. doi: 10.1007/s10549-015-3672-0

Table 4.

Single SNPs associations in genes with P ≤ 0.01

Gene, SNP Typea INFOb Allelesc RAFd (%) OR (95% CI)e, P value
All cases (3663) ER+ (1983) ER− (1098)
FGF1f
 rs143172501 I 0.87 T/C 3.6 1.31 (1.09-1.58), 0.005 1.04 (0.82-1.31), 0.77 1.88 (1.45-2.42), 1.4×10−6
FGFR2g
 rs10736303 G G/A 84.2 1.25 (1.14-1.38), 3.3×10−6 1.30 (1.16-1.47), 8.4×10−6 1.21 (1.05-1.40), 0.01
 rs3135774 I 0.99 G/C 2.2 1.47 (1.18-1.83), 4.9×10−4 1.62 (1.25-2.08), 2.1×10−4 1.34 (0.96-1.88), 0.09
MAPK3h
 rs78564187 G A/G 18.0 1.07 (0.98-1.16), 0.13 1.03 (0.93-1.14), 0.58 1.26 (1.17-1.35), 3.7×10−4
a

SNP type; imputed (I) or genotyped (G)

b

INFO score for imputed SNPs

c

Risk allele/reference allele

d

Risk allele frequency in AMBER

e

Adjusted for study site, age (10 year groupings), geographic region, DNA source (saliva, blood, mouthwash), and genotype principal components 5, 6, 8

f

SNP in the best 1-SNP model for ER− breast cancer

g

SNPs in the best 2-SNP model for all breast cancer and ER+ breast cancer

h

SNP in the best 1-SNP model for ER− breast cancer