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. Author manuscript; available in PMC: 2016 Jun 2.
Published in final edited form as: Xenotransplantation. 2014 Jan 21;21(1):1–10. doi: 10.1111/xen.12080

Figure 3. Histopathology following aortic valve and ascending aorta transplantation in rodent models [27].

Figure 3

Figure 3a demonstrates a syngeneic rat-to-rat aortic valve and ascending aorta transplant without any glutaraldehyde fixation (i.e., surgical negative control). Figure 3b demonstrates a glutaraldehyde-fixed syngeneic (rat-to-rat) transplant showing mild inflammation. Figures 3c demonstrates a glutaraldehyde-fixed xenogeneic (guinea pig-to-rat) transplant showing severe inflammation. Figure 3d demonstrates the reduction in inflammation when the rat recipient of the glutaraldehyde-fixed xenogeneic (guinea pig-to-rat) transplant is treated with steroids. V = aortic valve; m = media of aortic wall; ad = adventitia of aortic wall. (H&E x100 for 3a and x200 for 3b, 3c, 3d).