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. Author manuscript; available in PMC: 2016 Jun 2.
Published in final edited form as: Oncogene. 2013 Jun 10;33(22):2815–2825. doi: 10.1038/onc.2013.235

Figure 3.

Figure 3

SOX9 is downstream effector of ERG and AR in TMPRSS2:ERG fusion-positive PCa. SOX9 expression can be stimulated by extracellular signals including FGFs and HGF (mediated by their receptors and downstream ERK), and by WNTs though the canonical WNT/β-catenin pathway. AR in fusion-negative cells binds weakly to a site 5′ of the SOX9 gene (S1 site) and can weakly repress basal SOX9 expression (possibly by displacing positive transcription factors). In fusion-positive cells, ERG binds to a cryptic ARE 3′ of the SOX9 gene, with subsequent binding of FOXA1 and strong androgen-stimulated SOX9 expression.