Table 1.
Diversity of retrograde cargo sorting mechanisms
| Cargo | Sorting machinery | Sorting motif/region | Recognition | References |
|---|---|---|---|---|
| Cation-independent mannose phosphate receptor | Retromer/SNX1 or SNX2 | WLM | Retromer—VPS35 | [22, 92] |
| CED1 | Retromer/SNX1 or SNX6 | – | – | [130] |
| TGN38 | Retromer SNX2 | – | – | [131] |
| Vacuolar sorting receptor | SNX1 and SNX2 | – | Retromer—VPS35 | [132, 133] |
| BACE1 | Retromer/SNX6 | – | – | [134] |
| PIN1 and 2 | VPS29 and SNX1 | – | – | [135, 136] |
| SMA-6 | Retromer/SNX3 | – | Retromer—VPS35 | [137] |
| Rhodopsin1 | Retromer/SNX3/SNX1 | – | – | [138] |
| Wntless | Retromer/SNX3 | – | SNX3 | [63] |
| APOER2, LRP1, P-selectin, patched, APP | SNX17 | NPXY, FxNaa (F/Y) | SNX17 | [73, 75, 76, 79, 81, 83, 139] |
| Beta 1 integrins | SNX17/not retromer, SNX1–2 or SNX5–6 | Cyto tail | SNX17 | [74] |
| TRAILR1, CD97, beta-2 adrenergic receptor, GLUT1, MCT1 | Retromer/SNX27 | PDZ ligand | – | [84, 140] |
| SorLA | Retromer | FANSHY | VPS29 | [91] |
| Sortilin | Retromer | FLV or YXXϕ | VPS35/26 | [92, 141] |
| pIgA receptor | Retromer | – | – | [142] |
| Crumbs | Retromer | Cyto tail | Retromer | [143] |
| DMT1-II | Retromer | YLL | VPS35/26 | [93] |
| Yeast cargo | ||||
| Pep12, Ste13 | Retromer/Snx3 | – | – | [41, 144, 145] |
| Kex2 | Retromer/Snx3/Vps17?/Mvp1 | – | – | [145] |
| Fet3/Ftr1 | Retromer/Vps17/Vps5/Snx3 | Ftr1 cyto tail | Snx3 | [60] |
| Vps10 | Retromer/Vps17/Vps5?/Mvp1/NOT Snx3 | FVYF | – | [146] |
| Can1 | Retromer/Ere1 OR Snx4 family | – | – | [43] |
| Snc1 | Snx4 | – | Snx4 | [41] |
| Wsc1 | Retromer | – | – | [147] |