Table 1.
Patient Characteristics (N = 595)
| Characteristic | Treatment Regimen |
|||||
|---|---|---|---|---|---|---|
| Fludarabine-Based (n = 113) |
FC or FM (n = 137) |
FCR (n = 345) |
||||
| Median | Range | Median | Range | Median | Range | |
| Rai stage | ||||||
| 0 | 7 | 2 | 11 | |||
| I-II | 68 | 80 | 227 | |||
| III-IV | 35 | 55 | 106 | |||
| No. of nodal sites | ||||||
| 0 | 17 | 13 | 38 | |||
| 1 | 17 | 5 | 42 | |||
| 2 | 21 | 37 | 63 | |||
| 3 | 54 | 82 | 201 | |||
| Male sex | 71 | 92 | 245 | |||
| Age, years | 59 | 25-82 | 57 | 21-84 | 58 | 17-86 |
| WBC, 1,000/μL | 58.6 | 7-308 | 90 | 5-372 | 82 | 2-552 |
| ALC, 1,000/μL | 50.7 | 33-265 | 83 | 19-361 | 70 | 5-518 |
| ANC, 1,000/μL | 4.7 | 0-21.5 | 4.6 | 0-23.7 | 3.5 | 0-36.7 |
| HGB, g/dL | 12.9 | 5.7-17 | 12.3 | 7.7-16.2 | 12.6 | 6.1-18.7 |
| PLT, 1,000/μL | 169 | 26-450 | 140 | 24-414 | 156 | 8-419 |
| Creatinine, mg/dL | 1.0 | 0.5-1.8 | 1.1 | 0.7-7.1 | 1.1 | 0.5-9.2 |
| ALB, g/dL | 4.3 | 2.7-5.1 | 4.1 | 2.4-5.1 | 4.1 | 2.3-5.1 |
| Serum β-2M, mg/L | 2.9 | 1.4-12.5 | 3.3 | 1.2-11.8 | 3.7 | 1.5-16.4 |
| ALP, U/L | 87 | 40-418 | 81 | 40-362 | 81 | 18-223 |
| Uric acid, mg/dl | 6 | 2-9.8 | 5.6 | 0.6-10.8 | 5.8 | 1.0-12.6 |
| IgG, mg/dL | 848 | 188-4,650 | 736 | 45.0-3,160 | 740 | 89-5,000 |
| % BM prolymphocytes | 0 | 0-9 | 2.0 | 0.0-13.0 | 5 | 0-53 |
| % BM lymphocytes | 81 | 1.0-97 | 82 | 1-98 | 78 | 2-97 |
| Aspirate cellularity, % | 70 | 10.0-100 | 70 | 10-100 | 70 | 20-100 |
| BM biopsy cellularity, % | NA | 75 | 45-90 | 70 | 5-100 | |
| Spleen size, cm* | 0 | 0-22 | 0 | 0-20 | 1 | 0-22 |
| Liver size, cm* | 0 | 0-10 | 0 | 0-17 | 0 | 0-9 |
| Time from diagnosis to treatment, months | 7 | 0-145 | 17 | 0-307 | 24 | 0-156 |
| Follow-up all patients, months | 188 | 108 | 52 | |||
| Follow-up alive, months | 160 | 101 | 49 | |||
| Alive | ||||||
| No. | 26 | 58 | 284 | |||
| % | 23 | 43 | 82 | |||
Abbreviations: FC, fludarabine with cyclophosphamide; FM, fludarabine with mitoxantrone; FCR, fludarabine, cyclophosphamide, and rituximab; ALC, absolute lymphocyte count; ANC, absolute neutrophil count; HGB, hemoglobin; PLT, platelet; ALB, albumin; β-2M, β2 microglobulin; ALP, alkaline phosphatase; BM, bone marrow.
*
Measurement below costal margin.