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. 2016 Mar 9;5(4):409–417. doi: 10.1242/bio.015404

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© 2016. Published by The Company of Biologists Ltd

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

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Fig. 1. — Sox11 is expressed in differentiated neurons in vivo and in vitro and is dynamically expressed during mouse corticogenesis. (A-C) Wild type cerebral cortex hybridized with antisense probes specific for Sox11 at E14.5 (A), E17.5 (B) and P10 (C), with expression visualized using BM Purple. Sox11 is expressed in the cortical plate (CP) at E14.5 and E17.5. There is no detectable expression of Sox11 at P10. (D) In cultured cortical neurons examined after 3 days in vitro (3DIV), expression of Sox11 is localized to cells that are TuJ1⁺ (arrowheads) and absent from TuJ1⁻ cells (arrow). (E-F) Profile of Sox11 expression during cortical development in vivo (E) and in vitro (F) reveals undetectable levels early (E10.5-E12.5 and 1DIV), activation (E14.5-E18.5 and 4DIV), and inactivation (P0-P21 and 11DIV). CP, cortical plate; VZ, ventricular zone; SVZ, sub-ventricular zone; IZ, intermediate zone. Scale bar: 60 μm (A,B); 130 μm (C); 25 μm (D).