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. 2016 Mar 17;5(4):461–474. doi: 10.1242/bio.017368

Fig. 11.

Fig. 11.

Suggested model. (A) Based on data in this paper we suggest that PDGF-C expressed by neurons in the cerebral cortex is needed for proper organization of PDGFRα-positive meningeal fibroblasts, production of extracellular matrix proteins (ECM) and formation of the glial basement membrane. (B) Without PDGF-C, the arrangement of meningeal cells and ECM is irregular, no proper basement membrane is formed and cortical neurons can migrated out of the brain.