Skip to main content
. Author manuscript; available in PMC: 2016 Sep 22.
Published in final edited form as: Nat Immunol. 2016 Feb 15;17(4):461–468. doi: 10.1038/ni.3371

Figure 4.

Figure 4

Age is a major determinant of immunological equilibria. (a) Each immune parameter was correlated with age and each other immune parameter using pairwise Spearman r values. The arrangement of the immune parameters is determined by their correlation with age. Inset panels show Spearman’s r (upper) and -log10 Bonferroni corrected P values (lower) plotted against age. (b) R2 for each immune parameter for models incorporating gender (filled circles), age (grey squares) or both gender and age (open circles) as the independent variable(s), with (c) accompanying -log10 of Bonferroni corrected P values. (d) to (m) Individual scatterplots for each of the immune parameters with significant association with age. The percentage values of the flow parameters, or log10 cytokine concentrations, are plotted against age, with women in red, men in blue and linear regression lines for the whole cohort in black. Data shown for (d) CD4+ RTE (p=3x10-18), (e) transitional B cells (p=8x10-7), (f) CD8+ RTE (p=1x10-8), (g) TH1 (p=3x10-20), (h) CD4+ IL-2+ T cells (p=5x10-23), (i) Tc1 (p=5x10-31), (j) CD8+ IL-2+ T cells (p=8x10-33), (k) CD8+ T cells (p=8x10-11) (l) iNKT cells (p=6x10-10) and (m) serum IL-6 (p=7x10-11).