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. 2016 May 27;8:117–124. doi: 10.2147/BCTT.S106097

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© 2016 Isfoss et al. This work is published and licensed by Dove Medical Press Limited

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Round/oval cells according to family history.

Notes: DAPI nuclear staining (blue) and labeling of ALDH1 (green), CD44 (white), and CD24 (red). (A)–(B) Images showing the absence of ALDH1⁺ CD44⁺ CD24⁻ round/oval cells in a TDLU from a woman with a family history of breast cancer. Arrows indicate ALDH1⁻ CD44⁺ CD24⁻ cells. (C)–(D) Images illustrate an ALDH1⁺ CD44⁺ CD24⁻ round/oval-shaped cell (arrow) in a TDLU from a woman with no family history of breast cancer. (A) and (C) show only the ALDH1⁺ channel, and (B) and (D) show all four channels merged. Scale bars = 20 µm.

Abbreviations: DAPI, 4′,6-diamidino-2-phenylindole; TDLU, terminal duct-lobular unit.