Table 1.
Trade Name | Estrogen | Progestin | FDA Approved |
Dose |
---|---|---|---|---|
Hormonal Therapies | ||||
Premarin | CEE | — | Yes | 0.3–1.25 mg po daily |
Cenestin | Synthetic CE | — | Yes | 0.3–1.25 mg po daily |
Menest | Esterified estrogen | — | Yes | 0.3–1.25 mg po daily |
Estrace | 17β-estradiol | — | Yes | 1–2 mg po daily |
Estinyl | Ethinyl estradiol | — | Yes | 0.02–0.05 mg po 1–3 times daily |
Evamist | 17β-estradiol | — | Yes | 1–3 sprays daily |
Alora, Climara, Esclim, Menostar, Vivelle, Vivelle- Dot, Estraderm |
17β-estradiol | — | Yes | 1 patch weekly to twice weekly |
EstroGel | 17β-estradiol | — | Yes | 1.25 g daily transdermal gel (equivalent to 0.75 mg estradiol) |
Estrasorb | 17β-estradiol | — | Yes | 2 foil pouches daily of transdermal topical emulsion |
Activella | Estradiol 1 mg | NETA 0.5 mg | Yes | 1 tablet po daily |
Femhrt | Ethinyl estradiol 5 µg |
NETA 1 mg | Yes | 1 tab po daily |
Ortho-Prefest | 17β-estradiol 1 mg | Norgestimate 0.09 mg |
Yes | First 3 tablets contain estrogen, next 3 contain both hormones; alternate pills every 3 d |
Premphase | CEE 0.625 mg | MPA 5 mg | Yes | First 14 tablets contain estrogen only and remaining 14 tablets contain both hormones. 1 tab po daily |
Prempro | CEE 0.625 mg | MPA 2.5 or 5 mg |
Yes | 1 tab po daily |
CombiPatch | 17β-estradiol | NETA | Yes | 1 patch transdermal twice weekly |
Climara Pro | 17β-estradiol | LNG | Yes | 1 patch weekly |
Estrace | 17β-estradiol vaginal cream |
— | Yes | 2–4 g daily for 1 wk, then 1 g 3 times weekly |
Femring | Estradiol vaginal ring |
— | Yes | 1 ring inserted vaginally every 3 mo |
Duavee | CEE 0.45 mg/ bazedoxifine 20 mg |
— | Yes | 1 tablet daily |
Nonhormonal Therapies | ||||
Brisdelle | Paroxetinea 7.5 mg | — | Yes | 7.5 mg daily |
Effexor | Venlafaxine 36.5–300 mg |
— | No | 37.5–75 mg daily |
Pristiq | Desvenlafaxine | — | No | 50–100 mg daily |
Lexapro | Escitalopram | — | No | 10–20 mg daily |
Celexa | Citalopram | — | No | 10 mg daily |
Prozac | Fluoxetinea | — | No | 10–20 mg daily |
Zoloft | Sertraline | — | No | 50–100 mg daily |
Neurontin | Gabapentin | — | No | 300–900 mg up to tid |
Lyrica | Pregabalin | — | No | 50–10 mg tid |
Abbreviations: CE, conjugated estrogen; CEE, conjugated equine estrogen; LNG, levonorgestrel; MPA, medroxyprogesterone acetate; NETA, norethindrone acetate.
Inhibitor of CYP2D6; unsafe for use in conjunction with tamoxifen.