Table 1.

Hormonal and nonhormonal formulations for the treatment of hot flashes

Trade Name	Estrogen	Progestin	FDA Approved	Dose
Hormonal Therapies
Premarin	CEE	—	Yes	0.3–1.25 mg po daily
Cenestin	Synthetic CE	—	Yes	0.3–1.25 mg po daily
Menest	Esterified estrogen	—	Yes	0.3–1.25 mg po daily
Estrace	17β-estradiol	—	Yes	1–2 mg po daily
Estinyl	Ethinyl estradiol	—	Yes	0.02–0.05 mg po 1–3   times daily
Evamist	17β-estradiol	—	Yes	1–3 sprays daily
Alora, Climara,   Esclim, Menostar,   Vivelle, Vivelle-   Dot, Estraderm	17β-estradiol	—	Yes	1 patch weekly to   twice weekly
EstroGel	17β-estradiol	—	Yes	1.25 g daily   transdermal   gel (equivalent to   0.75 mg   estradiol)
Estrasorb	17β-estradiol	—	Yes	2 foil pouches daily   of   transdermal   topical   emulsion
Activella	Estradiol 1 mg	NETA 0.5 mg	Yes	1 tablet po daily
Femhrt	Ethinyl estradiol   5 µg	NETA 1 mg	Yes	1 tab po daily
Ortho-Prefest	17β-estradiol 1 mg	Norgestimate   0.09 mg	Yes	First 3 tablets   contain   estrogen, next 3   contain both   hormones;   alternate pills   every 3 d
Premphase	CEE 0.625 mg	MPA 5 mg	Yes	First 14 tablets   contain   estrogen only and   remaining 14   tablets   contain both   hormones. 1 tab po daily
Prempro	CEE 0.625 mg	MPA 2.5 or   5 mg	Yes	1 tab po daily
CombiPatch	17β-estradiol	NETA	Yes	1 patch transdermal   twice weekly
Climara Pro	17β-estradiol	LNG	Yes	1 patch weekly
Estrace	17β-estradiol   vaginal cream	—	Yes	2–4 g daily for 1 wk,   then 1 g 3 times   weekly
Femring	Estradiol vaginal   ring	—	Yes	1 ring inserted   vaginally   every 3 mo
Duavee	CEE 0.45 mg/   bazedoxifine   20 mg	—	Yes	1 tablet daily
Nonhormonal Therapies
Brisdelle	Paroxetinea 7.5 mg	—	Yes	7.5 mg daily
Effexor	Venlafaxine   36.5–300 mg	—	No	37.5–75 mg daily
Pristiq	Desvenlafaxine	—	No	50–100 mg daily
Lexapro	Escitalopram	—	No	10–20 mg daily
Celexa	Citalopram	—	No	10 mg daily
Prozac	Fluoxetinea	—	No	10–20 mg daily
Zoloft	Sertraline	—	No	50–100 mg daily
Neurontin	Gabapentin	—	No	300–900 mg up to   tid
Lyrica	Pregabalin	—	No	50–10 mg tid

Abbreviations: CE, conjugated estrogen; CEE, conjugated equine estrogen; LNG, levonorgestrel; MPA, medroxyprogesterone acetate; NETA, norethindrone acetate.

^aInhibitor of CYP2D6; unsafe for use in conjunction with tamoxifen.