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. Author manuscript; available in PMC: 2016 Jun 2.
Published in final edited form as: Endocrinol Metab Clin North Am. 2015 Sep;44(3):497–515. doi: 10.1016/j.ecl.2015.05.001

Table 4.

DSM-IV criteria for major depressive disorder and reasons for further psychiatric evaluation

Major Depression Indications for Further Psychiatric Evaluation
At least one of these must be present: Evidence of suicidal ideation, inability to care
  for self or dependent others, or
  aggressivity/homicidal ideation
  Depressed mood
  Loss of interest or pleasure in most or all
    activities

Four or more of the following must be
  present:
Failure to respond to or is intolerant of initial
  treatment trial
  Insomnia or hypersomnia Patient or clinician interested in modalities
  requiring specialty expertise
  (psychotherapy or electroconvulsive
  therapy, transcranial magnetic
  stimulation)
  Change in appetite or weight
  Psychomotor retardation or agitation
  Low energy
  Poor concentration
  Thoughts of worthlessness or guilt Psychotic symptoms present
  Recurrent thoughts about death or suicide History of bipolar disorder or psychotic
  disorder
Significant psychiatric comorbidity (anxiety
  disorders, substance use, cognitive
  disorder)
Unclear diagnosis of depression